Inhibitory Receptor Diffusion Dynamics

Diffusion dynamics of synaptic molecules during inhibitory postsynaptic plasticity

The plasticity of inhibitory transmission is expected to play a key role in the modulation of neuronal excitability and network function. Over the last two decades, the investigation of the determinants of inhibitory synaptic plasticity has allowed distinguishing presynaptic and postsynaptic mechanisms. While there has been a remarkable progress in the characterization of presynaptically-expres...

Modeling synaptic dynamics driven by receptor lateral diffusion.

The synaptic weight between a pre- and a postsynaptic neuron depends in part on the number of postsynaptic receptors. On the surface of neurons, receptors traffic by random motion in and out from a microstructure called the postsynaptic density (PSD). In the PSD, receptors can be stabilized at the membrane when they bind to scaffolding proteins. We propose a mathematical model to compute the po...

Activity-Dependent Tuning of Inhibitory Neurotransmission Based on GABAAR Diffusion Dynamics

An activity-dependent change in synaptic efficacy is a central tenet in learning, memory, and pathological states of neuronal excitability. The lateral diffusion dynamics of neurotransmitter receptors are one of the important parameters regulating synaptic efficacy. We report here that neuronal activity modifies diffusion properties of type-A GABA receptors (GABA(A)R) in cultured hippocampal ne...

Dynamics of expanding inhibitory fields.

Dynamics of Information Diffusion

Real diffusion networks are complex and dynamic, since underlying social structures are not only far-reaching beyond a single homogeneous system but also frequently changing with the context of diffusion. Thus, studying topic-related diffusion across multiple social systems is important for a better understanding of such realistic situations. Accordingly, this thesis focuses on uncovering topic...